�Eli Lilly and Co (NYSE:
LLY) and Boehringer Ingelheim experience announced that the European Commission
has approved the use of Cymbalta(R) (duloxetine) for the treatment of
Generalised Anxiety Disorder (GAD). This blessing -- the fourth for
duloxetine in Europe -- was issued on 28 July following an initial positive
opinion issued by the European Medicines Agency's (EMEA) Committee for
Medicinal Products for Human Use (CHMP) on 26 June 2008.
The approval is based upon the results of five-spot clinical studies of GAD
-- iV double-blind short-run (acute) placebo-controlled studies and a
placebo-controlled relapse bar study -- involving more than 2,000
non-depressed adults with GAD. In each of the four-spot acute placebo-controlled
studies safety and efficaciousness were assessed. Duloxetine significantly
improved core anxiety symptoms (as metrical by the Hamilton Anxiety Scale)
compared with placebo (p less than or equal to 0.001, p=0.02, p=0.007, p
less than or equal to 0.001 respectively)(1,2,3,4) and patients
demonstrated improvement in role operation, including power to perform
everyday activities in act, home and in social situations.(5,6) In
addition, duloxetine significantly decreased the likelihood of relapse in
those patients world Health Organization initially responded to duloxetine and were maintained on
treatment for six months compared with those switched to placebo.(7) The
most common side personal effects in these studies included nausea, fatigue, dry
mouth, drowsiness, irregularity, insomnia, reduced appetite,
hyperidrosis (excessive sudation), decreased libido, vomiting,
ejaculation delay and erectile dysfunction.
Although worldwide prevalence is not presently known, more than 9
million Europeans(8,9) and sestet million people in Central and South America
ar estimated to suffer from GAD(10), which is characterised by undue
anxiety and worry about a number of events and activities (such as
performance at work or school) over a free burning period of at least six
months.(11)
This regulatory blessing paves the way for launches in Europe and
applies to all 27 countries of the European Union, as well as Norway,
Iceland, and Liechtenstein.
Cymbalta(R), a member of a socio-economic class of drugs commonly referred to as
serotonin and noradrenaline re-uptake inhibitors,(12) is already approved by
the EMEA to care for major depressive disorder and diabetic peripheral
neuropathic pain in the neck. Duloxetine gained marketing authorization for the
treatment of GAD in Mexico in 2006 and in the United States in 2007.
About Generalised Anxiety Disorder
Approximately nine 1000000 Europeans(8,9) and six meg people in
Central and South America are estimated to endure from GAD.(10) Quality of
life is affected, as symptoms of GAD can include overstated worry or
chronic anxiousness, irritability and poor concentration. Ability to work is
often compromised with the manifestation of physical symptoms such as
muscle tension, fatigue, rest disturbance and nausea.(11) The illness
tends to be chronic with periods of exacerbation and remit. Patients
write up that episodes of generalized anxiety disorder are much brought on,
or worsened, by trying life events.(13)
About Duloxetine
While duloxetine's mechanics of action in humanity is non fully known, it
is believed to affect both serotonin- and
ntinence is marketed by Lilly under
the brand name Yentreve.(R)
References
(1) Koponen, H., et al. Efficacy of Duloxetine for the Treatment of
Generalized Anxiety Disorder: Implications for Primary Care Physicians.
Prim Care Companion J Clin Psychiatry 2007: 9(2):100-107
(2) Rynn M., et al. Efficacy and Safety of Duloxetine in the Treatment of
Generalized Anxiety Disorder: A Flexible-Dose, Progressive-Titration,
Placebo-Controlled Trial. Depression and Anxiety 2007: 25(3): 182-189.
(3) Hartford, J., et al. Duloxetine as an SNRI Treatment for Generalized
Anxiety Disorder: Results from a Placebo- and Active-Controlled Trial. Int
Clin Psychopharmacol 2007: 22(3):167-74.
(4) Nicolini H, et al. Improvement of psychic and somatic symptoms in
adult patients with generalized anxiety disorder: Examination from a
duloxetine, venlafaxine extended-release, and placebo-controlled report. In
Press at Psychological Medicine.
(5) Endicott, J., et al. Duloxetine Treatment for Role Functioning
Improvement in Generalized Anxiety Disorder: Three Independent Studies. The
Journal of Clinical Psychiatry 2007: 68(4):518-24
(6) Allgulander, C., et al. Pharmacotherapy of Generalized Anxiety
Disorder: Results of Duloxetine Treatment from a Pooled Analysis of 3
Clinical Trials. Current Medical Research and Opinion 2007: 23(6):
1245-1252
(7) Davidson JRT, et al. Duloxetine treatment for get worse prevention in
adults with generalized anxiety disorder: A 26-week randomised placebo-
controlled study. Poster presented at the American College of
Neuropsychopharmacology yearbook conference 2007. Boca Raton, Florida
(8) Lieb, R, et al. The epidemiology of generalised anxiety disorderliness in
Europe. European Neuropsychopharmacology 2005 Aug;15(4):445-52.
(9) National Institute of Economic and Social Research. Summarized from
the National Institute Economic Review,194, 28 October 2005.
(10) Calculated extrapolations of prevalence rates against the
populations of a particular country or region, based upon prevalence of
generalized anxiety disorder in the US, UK, Canada or Australia. Available
at:
hypertext transfer protocol://www.cureresearch.
Wednesday 3 September 2008
Sunday 24 August 2008
Mp3 music: Armando Manzanero
 Artist: Armando Manzanero: mp3 download Genre(s): Latin Rock Armando Manzanero's discography:  Canciones de Amor Year: 2006 Tracks: 14  Lo Mejor De Armando Manzanero Year: 2000 Tracks: 12  El Piano Year: 1995 Tracks: 13  Sus Grandes Interpretes... Cd 2 Year: Tracks: 20  Sus 26 grandes boleros Year: Tracks: 26  Los mejores duetos Year: Tracks: 33 Widely considered the prime Minister Mexican romanticist composer of the postwar earned course average, Armando Manzanero was born in the urban center of Mérida on December 7, 1935; after perusal at the local music indoor garden, he relocated to Mexico City in 1957 to follow up on a career as a performer and songster, soon authoring the Angelica MarÃa strike "Paso a Pasito." In 1960 he issued his first solo smash, "Voy a Apagar la Luz," followed over the age to sum by a string of hits including "Contigo AprendÃ," "Te Extraño," "Cuando Estoy Contigo," "Adoro," "No," "Esta Tarde Vi Llover" and "Tengo." Manzanero too released multitudinous LPs. |
Thursday 14 August 2008
NYFF well stocked with Cannes titles
'Changeling,' 'The Class' among festival entries
NEW YORK -- The North American premieres of Clint Eastwood's "Changeling," Darren Aronofsky's "The Wrestler" and a host of Festival de Cannes titles from Steven Soderbergh and other auteurs highlight the lineup of the 46th New York Film Festival.
The Centerpiece spot for "Changeling," from Universal/ Imagine, bolsters the Angelina Jolie-toplined Cannes incoming as a prime Oscar contender, as does the closing-night time slot for "Wrestler," with both prestige positions closely watched in the awards race.
Seventeen of the fest's 28 titles appeared at Cannes in May, including Soderbergh's four-hour-plus Spanish-language biopic "Che," and 20 are foreign-language features.
The NYFF runs Sept. 26-Oct. 12.
IFC Films has the most titles on the NYFF slate with four-spot: the Cannes Camera d'Or and FIPRESCI Critics Prize-winning "Hunger," the Grand Prix winner "Gomorra," "A Christmas Tale" and "Summer Hours." Sony Pictures Classics has three: the NYFF opening night film and Palme d'Or winner "The Class," Wong Kar Wai's "Ashes of Time Redux" and Ari Folman's "Waltz With Bashir."
Both distributors likely volition be on the hunt for more acquisitions following each company's record routine of Cannes buys, fueled by the large IFC In Theaters and newfangled IFC direct-to-VOD Festival Direct slates and SPC's 16-22 annual release slots to fill.
New distributor Oscilloscope Pictures is represented with the Cannes title "Wendy and Lucy," starring Michelle Williams, and Miramax has Mike Leigh's "Happy-Go-Lucky." A restored mark of Max Ophuls' last film, "Lola Montes" (Rialto Pictures), will be featured as the festival's glare retrospective film.
NYFF selection committee chairperson Richard Pena noted this year's with child crop of politically supercharged films and a wider number of countries delineate among both the slating (including deuce from Kazakhstan) and the 2,000-odd submissions. He attributes a recent uptick in submissions to the larger numeral of digitally filmed features.
"We're finding a lot of the most interesting work tends to make a statement," said Pena, citing a trend in stark contrast to the recent boxoffice downturn for issue-oriented indies.
"Class," "Changeling" and "Wrestler" will screen at the Ziegfeld Theatre throughout the festival. Most screenings at the Film Society of Lincoln Center event volition be held at the Walter Reade Theater.
A complete NYFF lineup follows:
Opening night
"The Class," Laurent Cantet, France (Sony Pictures Classics)
Centerpiece
"Changeling," Clint Eastwood, U.S. (Universal)
Closing night
"The Wrestler," Darren Aronofsky, U.S.
"24 City," Jia Zhangke, China/Hong Kong/Japan
"Afterschool," Antonio Campos, U.S.
"Ashes of Time Redux," Wong Kar Wai, Hong Kong (Sony Pictures Classics)
"Bullet in the Head," Jaime Rosales, Spain/France
"Che," Steven Soderbergh, France/Spain
"Chouga," Darezhan Omirbaev, France/Kazakhstan
"A Christmas Tale," Arnaud Desplechin, France (IFC Films)
"Four Nights With Anna," Jerzy Skolimowski, Poland/France
"Gomorrah," Matteo Garrone, Italy (IFC Films)
"Happy-Go-Lucky," Mike Leigh, U.K. (Miramax)
"The Headless Woman," Lucrecia Martel, Argentina/France/Italy/Spain
"Hunger," Steve McQueen, U.K. (IFC Films)
"I'm Going to Explode," Gerardo Naranjo, Mexico
"Let It Rain," Agnes Jaoui, France, 2008
Retrospective
"Lola Montes," Max Ophuls, France/West Germany (Rialto Pictures)
"Night and Day," Hong Sang-soo, South Korea, 2008
"The Northern Land," Joao Botelho, Portugal
"Serbis," Brillante Mendoza, Philippines/France
"Summer Hours," Olivier Assayas, France (IFC Films)
"Tokyo Sonata," Kiyoshi Kurosawa, Japan/Netherlands
"Tony Manero," Pablo Larrain, Chile/Brazil
"Tulpan," Sergey Dvortsevoy, Germany/Kazakhstan/Poland/Russia/Switzerland
"Waltz With Bashir," Ari Folman, Israel/Germany/France (Sony Pictures Classics)
"Wendy and Lucy," Kelly Reichardt, U.S. (Oscilloscope Pictures)
"The Windmill Movie," Alexander Olch, U.S.
More information
NEW YORK -- The North American premieres of Clint Eastwood's "Changeling," Darren Aronofsky's "The Wrestler" and a host of Festival de Cannes titles from Steven Soderbergh and other auteurs highlight the lineup of the 46th New York Film Festival.
The Centerpiece spot for "Changeling," from Universal/ Imagine, bolsters the Angelina Jolie-toplined Cannes incoming as a prime Oscar contender, as does the closing-night time slot for "Wrestler," with both prestige positions closely watched in the awards race.
Seventeen of the fest's 28 titles appeared at Cannes in May, including Soderbergh's four-hour-plus Spanish-language biopic "Che," and 20 are foreign-language features.
The NYFF runs Sept. 26-Oct. 12.
IFC Films has the most titles on the NYFF slate with four-spot: the Cannes Camera d'Or and FIPRESCI Critics Prize-winning "Hunger," the Grand Prix winner "Gomorra," "A Christmas Tale" and "Summer Hours." Sony Pictures Classics has three: the NYFF opening night film and Palme d'Or winner "The Class," Wong Kar Wai's "Ashes of Time Redux" and Ari Folman's "Waltz With Bashir."
Both distributors likely volition be on the hunt for more acquisitions following each company's record routine of Cannes buys, fueled by the large IFC In Theaters and newfangled IFC direct-to-VOD Festival Direct slates and SPC's 16-22 annual release slots to fill.
New distributor Oscilloscope Pictures is represented with the Cannes title "Wendy and Lucy," starring Michelle Williams, and Miramax has Mike Leigh's "Happy-Go-Lucky." A restored mark of Max Ophuls' last film, "Lola Montes" (Rialto Pictures), will be featured as the festival's glare retrospective film.
NYFF selection committee chairperson Richard Pena noted this year's with child crop of politically supercharged films and a wider number of countries delineate among both the slating (including deuce from Kazakhstan) and the 2,000-odd submissions. He attributes a recent uptick in submissions to the larger numeral of digitally filmed features.
"We're finding a lot of the most interesting work tends to make a statement," said Pena, citing a trend in stark contrast to the recent boxoffice downturn for issue-oriented indies.
"Class," "Changeling" and "Wrestler" will screen at the Ziegfeld Theatre throughout the festival. Most screenings at the Film Society of Lincoln Center event volition be held at the Walter Reade Theater.
A complete NYFF lineup follows:
Opening night
"The Class," Laurent Cantet, France (Sony Pictures Classics)
Centerpiece
"Changeling," Clint Eastwood, U.S. (Universal)
Closing night
"The Wrestler," Darren Aronofsky, U.S.
"24 City," Jia Zhangke, China/Hong Kong/Japan
"Afterschool," Antonio Campos, U.S.
"Ashes of Time Redux," Wong Kar Wai, Hong Kong (Sony Pictures Classics)
"Bullet in the Head," Jaime Rosales, Spain/France
"Che," Steven Soderbergh, France/Spain
"Chouga," Darezhan Omirbaev, France/Kazakhstan
"A Christmas Tale," Arnaud Desplechin, France (IFC Films)
"Four Nights With Anna," Jerzy Skolimowski, Poland/France
"Gomorrah," Matteo Garrone, Italy (IFC Films)
"Happy-Go-Lucky," Mike Leigh, U.K. (Miramax)
"The Headless Woman," Lucrecia Martel, Argentina/France/Italy/Spain
"Hunger," Steve McQueen, U.K. (IFC Films)
"I'm Going to Explode," Gerardo Naranjo, Mexico
"Let It Rain," Agnes Jaoui, France, 2008
Retrospective
"Lola Montes," Max Ophuls, France/West Germany (Rialto Pictures)
"Night and Day," Hong Sang-soo, South Korea, 2008
"The Northern Land," Joao Botelho, Portugal
"Serbis," Brillante Mendoza, Philippines/France
"Summer Hours," Olivier Assayas, France (IFC Films)
"Tokyo Sonata," Kiyoshi Kurosawa, Japan/Netherlands
"Tony Manero," Pablo Larrain, Chile/Brazil
"Tulpan," Sergey Dvortsevoy, Germany/Kazakhstan/Poland/Russia/Switzerland
"Waltz With Bashir," Ari Folman, Israel/Germany/France (Sony Pictures Classics)
"Wendy and Lucy," Kelly Reichardt, U.S. (Oscilloscope Pictures)
"The Windmill Movie," Alexander Olch, U.S.
More information
Wednesday 6 August 2008
Friday 27 June 2008
Corrie star named Celeb Mum of the Year
'Coronation Street' star Kym Ryder has been named Celebrity Mum of the Year by Tesco Magazine.
The 31-year-old actress, who plays barmaid Michelle Connor in the soap, has two children, 12-year-old David and 10-year-old Emily.
The actress was reportedly chosen as Celebrity Mum of the Year because of her ability to balance her acting and charity work with her family life.
Ryder said: "I'm shocked and thrilled to have won this award from Tesco Magazine. And I feel humbled to have won alongside such amazing mums, whose stories are truly incredible."
"I'll be bringing lots of tissues to the awards ceremony as I know it will be a really emotional and inspiring day."
The 31-year-old actress, who plays barmaid Michelle Connor in the soap, has two children, 12-year-old David and 10-year-old Emily.
The actress was reportedly chosen as Celebrity Mum of the Year because of her ability to balance her acting and charity work with her family life.
Ryder said: "I'm shocked and thrilled to have won this award from Tesco Magazine. And I feel humbled to have won alongside such amazing mums, whose stories are truly incredible."
"I'll be bringing lots of tissues to the awards ceremony as I know it will be a really emotional and inspiring day."
Thursday 19 June 2008
Bobby Brown - Bobby Browns Son Exposes Houston As Poor Stepmother
BOBBY BROWN's son LANDON has revealed his former stepmother, WHITNEY HOUSTON, treated him like an employee when he went to stay with the former couple.
Landon Brown says Houston was a "nightmare" to grow up with, refusing to accept him as a member of her family.
He tells the National Enquirer that his former stepmum insisted he slept in a guest house when he came to stay - and refused to let him spend time with her daughter - his half-sister - Bobbi Kristina.
He says, "Whitney and I never really got along. She didn't necessarily hate me, but she wouldn't really speak to me either. In Whitney's eyes, I was the stepchild."
He adds, "She decided to turn me into one of her security personnel. I was a teenager but I was walking around dressed up in all black with a Security shirt and she'd have me work for her. I was just another one of her staff."
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