Cymbalta Receives European Approval For The Treatment Of Generalised Anxiety Disorder

�Eli Lilly and Co (NYSE:
LLY) and Boehringer Ingelheim experience announced that the European Commission
has approved the use of Cymbalta(R) (duloxetine) for the treatment of
Generalised Anxiety Disorder (GAD). This blessing -- the fourth for
duloxetine in Europe -- was issued on 28 July following an initial positive
opinion issued by the European Medicines Agency's (EMEA) Committee for
Medicinal Products for Human Use (CHMP) on 26 June 2008.



The approval is based upon the results of five-spot clinical studies of GAD
-- iV double-blind short-run (acute) placebo-controlled studies and a
placebo-controlled relapse bar study -- involving more than 2,000
non-depressed adults with GAD. In each of the four-spot acute placebo-controlled
studies safety and efficaciousness were assessed. Duloxetine significantly
improved core anxiety symptoms (as metrical by the Hamilton Anxiety Scale)
compared with placebo (p less than or equal to 0.001, p=0.02, p=0.007, p
less than or equal to 0.001 respectively)(1,2,3,4) and patients
demonstrated improvement in role operation, including power to perform
everyday activities in act, home and in social situations.(5,6) In
addition, duloxetine significantly decreased the likelihood of relapse in
those patients world Health Organization initially responded to duloxetine and were maintained on
treatment for six months compared with those switched to placebo.(7) The
most common side personal effects in these studies included nausea, fatigue, dry
mouth, drowsiness, irregularity, insomnia, reduced appetite,
hyperidrosis (excessive sudation), decreased libido, vomiting,
ejaculation delay and erectile dysfunction.



Although worldwide prevalence is not presently known, more than 9
million Europeans(8,9) and sestet million people in Central and South America
ar estimated to suffer from GAD(10), which is characterised by undue
anxiety and worry about a number of events and activities (such as
performance at work or school) over a free burning period of at least six
months.(11)



This regulatory blessing paves the way for launches in Europe and
applies to all 27 countries of the European Union, as well as Norway,
Iceland, and Liechtenstein.



Cymbalta(R), a member of a socio-economic class of drugs commonly referred to as
serotonin and noradrenaline re-uptake inhibitors,(12) is already approved by
the EMEA to care for major depressive disorder and diabetic peripheral
neuropathic pain in the neck. Duloxetine gained marketing authorization for the
treatment of GAD in Mexico in 2006 and in the United States in 2007.

About Generalised Anxiety Disorder



Approximately nine 1000000 Europeans(8,9) and six meg people in
Central and South America are estimated to endure from GAD.(10) Quality of
life is affected, as symptoms of GAD can include overstated worry or
chronic anxiousness, irritability and poor concentration. Ability to work is
often compromised with the manifestation of physical symptoms such as
muscle tension, fatigue, rest disturbance and nausea.(11) The illness
tends to be chronic with periods of exacerbation and remit. Patients
write up that episodes of generalized anxiety disorder are much brought on,
or worsened, by trying life events.(13)

About Duloxetine



While duloxetine's mechanics of action in humanity is non fully known, it
is believed to affect both serotonin- and
ntinence is marketed by Lilly under
the brand name Yentreve.(R)

References



(1) Koponen, H., et al. Efficacy of Duloxetine for the Treatment of
Generalized Anxiety Disorder: Implications for Primary Care Physicians.
Prim Care Companion J Clin Psychiatry 2007: 9(2):100-107



(2) Rynn M., et al. Efficacy and Safety of Duloxetine in the Treatment of
Generalized Anxiety Disorder: A Flexible-Dose, Progressive-Titration,
Placebo-Controlled Trial. Depression and Anxiety 2007: 25(3): 182-189.



(3) Hartford, J., et al. Duloxetine as an SNRI Treatment for Generalized
Anxiety Disorder: Results from a Placebo- and Active-Controlled Trial. Int
Clin Psychopharmacol 2007: 22(3):167-74.



(4) Nicolini H, et al. Improvement of psychic and somatic symptoms in
adult patients with generalized anxiety disorder: Examination from a
duloxetine, venlafaxine extended-release, and placebo-controlled report. In
Press at Psychological Medicine.



(5) Endicott, J., et al. Duloxetine Treatment for Role Functioning
Improvement in Generalized Anxiety Disorder: Three Independent Studies. The
Journal of Clinical Psychiatry 2007: 68(4):518-24



(6) Allgulander, C., et al. Pharmacotherapy of Generalized Anxiety
Disorder: Results of Duloxetine Treatment from a Pooled Analysis of 3
Clinical Trials. Current Medical Research and Opinion 2007: 23(6):
1245-1252



(7) Davidson JRT, et al. Duloxetine treatment for get worse prevention in
adults with generalized anxiety disorder: A 26-week randomised placebo-
controlled study. Poster presented at the American College of
Neuropsychopharmacology yearbook conference 2007. Boca Raton, Florida



(8) Lieb, R, et al. The epidemiology of generalised anxiety disorderliness in
Europe. European Neuropsychopharmacology 2005 Aug;15(4):445-52.



(9) National Institute of Economic and Social Research. Summarized from
the National Institute Economic Review,194, 28 October 2005.



(10) Calculated extrapolations of prevalence rates against the
populations of a particular country or region, based upon prevalence of
generalized anxiety disorder in the US, UK, Canada or Australia. Available
at:
hypertext transfer protocol://www.cureresearch.

Mp3 music: Armando Manzanero

Artist: Armando Manzanero: mp3 download    Genre(s):  Latin Rock     Armando Manzanero's discography:      Canciones de Amor    Year: 2006    Tracks: 14      Lo Mejor De Armando Manzanero    Year: 2000    Tracks: 12      El Piano    Year: 1995    Tracks: 13      Sus Grandes Interpretes... Cd 2    Year:     Tracks: 20      Sus 26 grandes boleros    Year:     Tracks: 26      Los mejores duetos    Year:     Tracks: 33 Widely considered the prime Minister Mexican romanticist composer of the postwar earned course average, Armando Manzanero was born in the urban center of Mérida on December 7, 1935; after perusal at the local music indoor garden, he relocated to Mexico City in 1957 to follow up on a career as a performer and songster, soon authoring the Angelica María strike "Paso a Pasito." In 1960 he issued his first solo smash, "Voy a Apagar la Luz," followed over the age to sum by a string of hits including "Contigo Aprendí," "Te Extraño," "Cuando Estoy Contigo," "Adoro," "No," "Esta Tarde Vi Llover" and "Tengo." Manzanero too released multitudinous LPs.

NYFF well stocked with Cannes titles

'Changeling,' 'The Class' among festival entries





NEW YORK -- The North American premieres of Clint Eastwood's "Changeling," Darren Aronofsky's "The Wrestler" and a host of Festival de Cannes titles from Steven Soderbergh and other auteurs highlight the lineup of the 46th New York Film Festival.

The Centerpiece spot for "Changeling," from Universal/ Imagine, bolsters the Angelina Jolie-toplined Cannes incoming as a prime Oscar contender, as does the closing-night time slot for "Wrestler," with both prestige positions closely watched in the awards race.

Seventeen of the fest's 28 titles appeared at Cannes in May, including Soderbergh's four-hour-plus Spanish-language biopic "Che," and 20 are foreign-language features.

The NYFF runs Sept. 26-Oct. 12.

IFC Films has the most titles on the NYFF slate with four-spot: the Cannes Camera d'Or and FIPRESCI Critics Prize-winning "Hunger," the Grand Prix winner "Gomorra," "A Christmas Tale" and "Summer Hours." Sony Pictures Classics has three: the NYFF opening night film and Palme d'Or winner "The Class," Wong Kar Wai's "Ashes of Time Redux" and Ari Folman's "Waltz With Bashir."

Both distributors likely volition be on the hunt for more acquisitions following each company's record routine of Cannes buys, fueled by the large IFC In Theaters and newfangled IFC direct-to-VOD Festival Direct slates and SPC's 16-22 annual release slots to fill.

New distributor Oscilloscope Pictures is represented with the Cannes title "Wendy and Lucy," starring Michelle Williams, and Miramax has Mike Leigh's "Happy-Go-Lucky." A restored mark of Max Ophuls' last film, "Lola Montes" (Rialto Pictures), will be featured as the festival's glare retrospective film.

NYFF selection committee chairperson Richard Pena noted this year's with child crop of politically supercharged films and a wider number of countries delineate among both the slating (including deuce from Kazakhstan) and the 2,000-odd submissions. He attributes a recent uptick in submissions to the larger numeral of digitally filmed features.

"We're finding a lot of the most interesting work tends to make a statement," said Pena, citing a trend in stark contrast to the recent boxoffice downturn for issue-oriented indies.

"Class," "Changeling" and "Wrestler" will screen at the Ziegfeld Theatre throughout the festival. Most screenings at the Film Society of Lincoln Center event volition be held at the Walter Reade Theater.

A complete NYFF lineup follows:

Opening night

"The Class," Laurent Cantet, France (Sony Pictures Classics)

Centerpiece

"Changeling," Clint Eastwood, U.S. (Universal)

Closing night

"The Wrestler," Darren Aronofsky, U.S.
"24 City," Jia Zhangke, China/Hong Kong/Japan
"Afterschool," Antonio Campos, U.S.
"Ashes of Time Redux," Wong Kar Wai, Hong Kong (Sony Pictures Classics)
"Bullet in the Head," Jaime Rosales, Spain/France
"Che," Steven Soderbergh, France/Spain
"Chouga," Darezhan Omirbaev, France/Kazakhstan
"A Christmas Tale," Arnaud Desplechin, France (IFC Films)
"Four Nights With Anna," Jerzy Skolimowski, Poland/France
"Gomorrah," Matteo Garrone, Italy (IFC Films)
"Happy-Go-Lucky," Mike Leigh, U.K. (Miramax)
"The Headless Woman," Lucrecia Martel, Argentina/France/Italy/Spain
"Hunger," Steve McQueen, U.K. (IFC Films)
"I'm Going to Explode," Gerardo Naranjo, Mexico
"Let It Rain," Agnes Jaoui, France, 2008

Retrospective

"Lola Montes," Max Ophuls, France/West Germany (Rialto Pictures)
"Night and Day," Hong Sang-soo, South Korea, 2008
"The Northern Land," Joao Botelho, Portugal
"Serbis," Brillante Mendoza, Philippines/France
"Summer Hours," Olivier Assayas, France (IFC Films)
"Tokyo Sonata," Kiyoshi Kurosawa, Japan/Netherlands
"Tony Manero," Pablo Larrain, Chile/Brazil
"Tulpan," Sergey Dvortsevoy, Germany/Kazakhstan/Poland/Russia/Switzerland
"Waltz With Bashir," Ari Folman, Israel/Germany/France (Sony Pictures Classics)
"Wendy and Lucy," Kelly Reichardt, U.S. (Oscilloscope Pictures)
"The Windmill Movie," Alexander Olch, U.S.


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Motorcycle

   
Artist: Motorcycle

   Genre(s): 
Trance: Psychedelic
   

---

Discography:


   
 As The Rush Comes

   Year:    
Tracks: 4

---

 

Corrie star named Celeb Mum of the Year

'Coronation Street' star Kym Ryder has been named Celebrity Mum of the Year by Tesco Magazine.
The 31-year-old actress, who plays barmaid Michelle Connor in the soap, has two children, 12-year-old David and 10-year-old Emily.
The actress was reportedly chosen as Celebrity Mum of the Year because of her ability to balance her acting and charity work with her family life.
Ryder said: "I'm shocked and thrilled to have won this award from Tesco Magazine. And I feel humbled to have won alongside such amazing mums, whose stories are truly incredible."
"I'll be bringing lots of tissues to the awards ceremony as I know it will be a really emotional and inspiring day."

Bobby Brown - Bobby Browns Son Exposes Houston As Poor Stepmother

BOBBY BROWN's son LANDON has revealed his former stepmother, WHITNEY HOUSTON, treated him like an employee when he went to stay with the former couple.

Landon Brown says Houston was a "nightmare" to grow up with, refusing to accept him as a member of her family.

He tells the National Enquirer that his former stepmum insisted he slept in a guest house when he came to stay - and refused to let him spend time with her daughter - his half-sister - Bobbi Kristina.

He says, "Whitney and I never really got along. She didn't necessarily hate me, but she wouldn't really speak to me either. In Whitney's eyes, I was the stepchild."

He adds, "She decided to turn me into one of her security personnel. I was a teenager but I was walking around dressed up in all black with a Security shirt and she'd have me work for her. I was just another one of her staff."

See Also

• Rufus Sewell - 62nd Tony Awards Nominees Announced
• Michael Lohan: ‘Lindsay’s Lesbian Affair Is Evident To Anyone With Half A Brain’
• ASK MICK LASALLE, Chronicle Movie Critic
• Joan Jett to get signature Gibson guitar

Goldenboy

   
Artist: Goldenboy

   Genre(s): 
Other
   

---

Discography:


   
 Or

   Year: 2004   
Tracks: 12

---

 

Locos Incorporated

   
Artist: Locos Incorporated

   Genre(s): 
Other
   

---

Discography:


   
 Emotional Cookies

   Year: 2003   
Tracks: 12

---

 





Britain's Got Talent: Simon Cowell: 'Faryl Smith Will Earn �20m Before She's 20'

Ion Dissonance

   
Artist: Ion Dissonance

   Genre(s): 
Metal: Alternative
   

---

Discography:


   
 Breathing Is Irrelevant

   Year: 2003   
Tracks: 9


   
 .357 (EP)

   Year: 2003   
Tracks: 2

---

Canadian masters of metallic hard-core, Ion Dissonance combine precise stop-on-a-dime drumming and a phrenetic, hefty guitar attack with songs that assault with the force of a pestiferous thermonuclear device to create something young and operose on the alloy scene. Ion Dissonance were formed in Montreal, Quebec in mid-2002 by guitarists Sebastien Chaput and Antoine Lussier and drummer J.F. Richard, alloy fans interested in pickings the music to modern sonic extremes. Teaming with vocalizer Gabriel McCaughry and bassist Sebastien Painchaud, Ion Dissonance recorded their first demonstration in the fall of 2002, and it was released to fans under the title .357 by the end of the year. The demonstration EP earned the set positive press care and Ion Dissonance began sharing stages with the likes of the Dillinger Escape Plan, Every Time I Die and the Black Dahlia Murder. In the spring of 2003, Ion Dissonance began work on their get-go uncut album, only non before bassist Painchaud leftfield the group, to be replaced by Miguel Valade. Pennsylvania-based metal label Willowtip Records released Ion Dissonance's debut album, External respiration Is Irrelevant, in the fall of 2003, with an American turn following early in 2004. The radical continued to spell passim Canada and the United States through the catch one's breath of 2004, though bassist Valade would voice company with Ion Dissonance late in the year. In early 2005, Xavier St. Laurent took over on bass, and the band continued their punishing route agenda, pickings a break in May to begin exercise on their mo album, Solace, which would be released by Abacus Recordings in September 2005. More roadwork followed, including appearances at many of North America's leading extreme metal festivals, and a tear CD with Despised Icon featuring uncommon demonstration material was released in June of 2006. That same calendar month, vocalist McCaughry proclaimed he was going away Ion Dissonance due to creative differences, and in the fall, the band disclosed that Kevin McCaughey, erstwhile of the group Shaolin, had signed on as their fresh isaac Merrit Singer, in fourth dimension to begin transcription on the group's adjacent album, Negative the Herd, which was released by Abacus in June 2007.

Writer Pratchett has Alzheimer's

Writer Pratchett has Alzheimer's

The bestselling 'Discworld' source Dame Ellen Terry Pratchett has revealed that he has a rare var. of early oncoming Alzheimer's disease.
In a program line, released on the internet site of 'Discworld' artist Alice Paul Kidby, the generator said: "I would feature liked to retain this single tranquility for a little spell, but because of upcoming conventions and of row the demand to keep my publishers informed, it seems to me unfair to withhold the news."
He continued: "I have been diagnosed with a very rare form of early oncoming Alzheimer's disease, which lay in arrears this year's phantom 'stroke'."
"We are taking it clean philosophically pour down hither and mayhap with a mild optimism," he added.
The 59-year-old described the diagnosing as "an embuggerance" and said that thither was "time for at least a few more books all the same".
Pratchett is continuing work on his fresh book 'Nation' and has been preparing for another novel, 'Unseen Academicals'.
He was told by doctors during the summertime that he had suffered a mini-stroke in recent eld but had been unaware of it. The author had checkup tests followers problems with his hand-eye coordination and manual dexterity.
In his argument Pratchett concluded: "PS: I would barely like to take out attending to everyone reading the higher up that this should be interpreted as 'I am non dead'."
"I will, of grade, be dead at approximately future point, as will everybody else.
"For me, this may be further away than you mean - it's to a fault soon to tell.
"I know it's a very man thing to say 'Is there anything I crapper do', but in this case I would only think of offers from very high-end experts in brain chemistry."




Oppressed

Courteney Cox, husband try for another baby

Courteney Cox, husband try for another baby

Courteney Coxswain and her hubby, David Arquette, are trying for another baby.
The couple are keen for their three year old girl Coconut palm to have a little blood brother or sis and are said to be undergoing IVF treatment.
The former ‘Friends’ star topology and the player — wHO tied the international nautical mile in 1999 — ab initio clashed over their family unit plans because Courteney, 43, wanted to focus on her fresh US TV show ‘Dirt’.
A source said: “David was fix to start trying for a baby once more, only Courteney wasn’t and she had a wax schedule of filming to contend with.

Tokyo Gakusho and Seki Hiroko

   
Artist: Tokyo Gakusho and Seki Hiroko

   Genre(s): 
Other
   

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Discography:


   
 Genji Monogatari no Ongaku

   Year: 1991   
Tracks: 6

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Andres Roca

   
Artist: Andres Roca

   Genre(s): 
New Age
   

---

Discography:


   
 Whispers In The Night

   Year: 1996   
Tracks: 6

---

 





L'usine

Gratitude

   
Artist: Gratitude

   Genre(s): 
Other
   

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Discography:


   
 Gratitude

   Year: 2005   
Tracks: 12

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Gratitude included Jonah Matranga of Far and Onelinedrawing and ex-Crumb guitar player Marking Steven Weinberg, rounded come out by bassist Cork Lindsey, guitar instrumentalist Jeremy Tappero, and drummer Dave Jarnstrom. In March 2005 the San Francisco-based portion issued its self-titled Atlantic Ocean debut, a merry correct that looked to Weezer and Jimmy Use up World for influence.

Miller amongst BAFTA rising star nominees

Miller amongst BAFTA rising star nominees

Sienna Milling machine has been nominated for this year's Rebellion Star accolade at the BAFTAs.
The actress, wHO late appeared in 'Stardust', is amongst two British people stars nominated for the laurels, which is voted for by the world. Surface-to-air missile James Whitcomb Riley, the star of Joy Division biopic 'Control', is the other Brits nominee.
They're joined in the category by Ellen Page, Shia LaBeouf and 'Lust, Caution' star Black rockweed Wei for the award.
The category was established in honour of late casting film director Blessed Virgin Selway, wHO died in 2004, with Scots English actor William James McAvoy picking up the inaugural awarding.
'Casino Royale' star Eva Green, wHO north Korean won the honour last year, announced the nominees saying: "This year's five nominees are wholly actors world Health Organization get actually stood out in their mold and I'm sure enough we'll examine a lot more of them passim 2008."
The succeeder will be announced at the official BAFTA ceremony on 10 February.